One of the ultimate goals of medicinal chemistry is to develop medicines to treat a specific disease. As an example, some years ago we designed a new class of highly active pyrrole antitubercular agents and also developed a novel biocatalytic methodology to synthesise such heterocycles in a milder, greener and more sustainable way. In parallel, as an organic chemist, I like to explore novel synthetic methodologies to prepare such drugs or drug building blocks in faster, smarter and more sustainable ways than the existing ones, mainly exploiting enzymes and biocatalysis. As a medicinal chemist, I am interested in the design and identification of new antibacterial drugs with the aim to give my contribution to the fight against antimicrobial resistance. Nevertheless, I never lost sight of medicinal chemistry, so that, when I started my independent career, I decided to split my research activity into two interconnected themes: drug discovery and the development of catalytic synthetic methodologies. During my PhD, I also started to develop an interest for organic chemistry, that led me to carry out postdoctoral studies in catalysis and organic synthesis, with Prof. Maurizio Botta, where I had a chance to work on the design and synthesis of antibacterial drugs as well as on the development of catalytic methodologies to access drugs and drug precursors through alternative and more efficient ways. Such interest pushed me to continue my studies with a PhD in medicinal chemistry in the research group of Prof. I became attracted to synthetic chemistry and its applications to the synthesis and design of drugs during my undergraduate studies in medicinal chemistry at the University of Siena.
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